Tab: Alcohol, ACE inhibitors, cimetidine, ketotifen, linezolid, MAOIs. SR tab: Increased peak plasma/whole blood conc & whole blood AUC w/ cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, & vancomycin). Reduced urinary excretion & increased plasma conc w/ cimetidine. Hypoglycemia w/ other antidiabetics (eg, sulfonylureas, meglitinides, glitazones, or insulin). May exacerbate DM w/ thiazide diuretics. May increase absorption, C
max, AUC & excretion w/ nifedipine. May impair glucose tolerance, mask the true frequency or severity of hypoglycemia, block hypoglycemia-induced tachycardia (but not hypoglycemic sweating), delayed rate of recovery of blood glucose conc following drug-induced hypoglycemia, & impair peripheral circulation w/ β-adrenergic blocking agents (eg, propranolol, nadolol). May reduce fasting blood glucose conc w/ ACE inhibitors (eg, captopril, enalapril). Increased risk of hypoglycemia & lactic acidosis w/ alcohol (acute or chronic intake). May increase ovulatory response w/ clomifene in premenopausal w/ PCOS. May affect the pharmacokinetic properties of coumarin anticoagulants. May lead to renal failure & risk of lactic acidosis w/ iodinated contrast media. Decreased C
max & blood AUC of glyburide. Hyperglycemia & may exacerbate loss of glycemic control w/ thiazides & other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, OCs, phenytoin, nicotinic acid, sympathomimetics, Ca channel blocking drugs, & INH.